Anticuerpos antifosfatidilserina/protrombina en pacientes con poliarteritis nodosa / Anti-Phosphatidylserine/Prothrombin antibodies in patients with Polyarteritis Nodosa
Reumatol. clín. (Barc.)
; 17(9): 521-524, Nov. 2021.
Article
in Es
| IBECS
| ID: ibc-213357
Responsible library:
ES1.1
Localization: ES15.1 - BNCS
RESUMEN
Antecedentes Anticuerpos antifosfatidilserina/protrombina (aPS/PT) han sido descritos en poliarteritis nodosa (PAN) cutánea, en asociación con manifestaciones específicas. Objetivos:
Determinar anticuerpos aPS/PT en pacientes con PAN y analizar su correlación con manifestaciones clínicas.Métodos:
Estudio transversal comparativo de pacientes con PAN y 20 controles (10 con poliangitis microscópica [PAM] y 10 con enfermedad de Behçet [EB]). Se evaluaron variables demográficas, clínicas, serológicas y tratamiento; índices de pronóstico, actividad y daño. Se determinaron anticuerpos aPS/PT, anticardiolipina (aCL), anti-beta 2 glicoproteína 1 (anti-B2GP1) y anticoagulante lúpico (AL).Resultados:
Fueron incluidos 14 pacientes con PAN, 11 (79%) mujeres, con duración de la enfermedad de 207 meses, y principalmente enfermedad inactiva. Sólo un paciente con PAN y uno con EB fueron positivos para aPS/PT IgG. El anticuerpo antifosfolípido más frecuente fue AL. Un paciente con PAM y uno con EB fueron positivos para aCL IgM; uno con PAM para anti-B2GP1 IgG, uno con PAN para anti-B2GP1 IgM.Conclusiones:
Los anticuerpos aPS/PT son infrecuentes en pacientes con PAN inactiva de larga evolución.(AU)ABSTRACT
Introduction:
Anti-phosphatidylserine/prothrombin (aPS/PT) antibodies have been described in cutaneous Polyarteritis Nodosa (PAN) in association with specific manifestations.Objectives:
To determine aPS/PT antibodies in patients with PAN and its correlation with clinical manifestations.Methods:
Cross-sectional comparative study including PAN patients and 20 controls (10 Microscopic Polyangiitis [MPA] and 10 Behçet's disease [BD]). Clinical and demographic variables, treatment, serological markers, prognosis, activity and damage indexes were evaluated. aPS/PT, anti-cardiolipin (aCL), anti-beta 2 glycoprotein 1 (anti-B2GP1) antibodies, and lupus anticoagulant (LA) were determined.Results:
Fourteen patients with PAN were included, 11 (79%) women, with disease duration of 207 months, and mostly inactive disease. Only one patient with PAN and one with BD were positive for aPS/PT IgG. LA was the most frequent antibody identified. One patient with MPA and one with BD were positive for aCL IgM; one with MPA for anti-B2GP1 IgG, and one with PAN for anti-B2GP1 IgM.Conclusions:
aPS/PT antibodies are not frequent in patients with longstanding inactive PAN.(AU)Key words
Full text:
1
Collection:
06-national
/
ES
Database:
IBECS
Main subject:
Polyarteritis Nodosa
/
Phosphatidylserines
/
Vasculitis
/
Prothrombin
/
Angiography
/
29161
/
Antibodies, Antiphospholipid
/
Correlation of Data
Limits:
Female
/
Humans
/
Male
Language:
Es
Journal:
Reumatol. clín. (Barc.)
Year:
2021
Document type:
Article